Harlequins are taking on a Leicester Tigers side hoping to cement their place in the final four in the Gallagher Premiership this season.
Quins have struggled on the road this season, having not won away from The Stoop in all competitions since 2nd December last year and will be hoping to end that in their final game.
Leicester are third as things stand and could confirm their semi-final tie against Sale Sharks rather than Saracens with victory this weekend.
Kick-off at Mattioli Woods Welford Road is at 4pm on Saturday.
Teddington RFC have the chance to cap their perfect season with victory at Twickenham against Wensleydale in the cup final this weekend.
Victory in the semi-finals means that the Antlers have made it to the final game of the season having won every match so far and could complete this dream run with victory at Twickenham Stadium this Sunday.
Wensleydale won Counties 2 Yorkshire on their way to this point and have managed to navigate knock-out ties against Harrogate Pythons, Mansfield, and East Grinstead on route to the showpiece final.
Kick-off at Twickenham Stadium is at 1pm on Sunday.
Ealing Trailfinders will be looking to bounce straight back from missing out on the league title as they face Doncaster Knights in the Championship cup semi-finals.
Despite leading the race for the RFU Championship title for the majority of the season, defeat in the penultimate game against Jersey Reds saw them miss out and having successfully finished above Jersey in the group stages, they are hoping to win their third straight Championship Cup.
Doncaster finished the season in 6th in the Championship and lost to Ealing on the final day of the season to continue a run of one win in four matches to end their league campaign.
Kick-off at Trailfinders Sports Park is at 3pm on Saturday.
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