A 30-metre high mural could be built on the side of a Twickenham office block if plans are signed off by Richmond Council.
Iceni Projects has applied for planning permission for the gigantic piece of art, which would be the latest in an international series aiming to promote the "revival of ecosystems".
Plans state the proposed London Road mural - which would be 15.24m by 30.48m - is called 'N6tur3' and has been designed by Street Art for Mankind (SAM).
The piece is "inspired by the classic figure of mother nature".
The application explains: "In his typical futuristic yet classical style, the artist proposes a poetic vision of the future where cities and nature make one in harmony.
"With this anthropomorphic tree the artist suggests a strong bond between man and nature.
"The metamorphosis of the city of London into a river landscape is also intended to suggest the future possibility of transformation and balance between humanity and nature."
SAM has partnered with the United Nations to help promote its Decade on Ecosystem Restoration, by launching a massive 10-year mural campaign (2021- 2030) of "Ecosystem Restoration Murals".
SAM is creating 50 murals to raise awareness amongst the public on the "critical need to halt, prevent and reverse ecosystem degradation", and to "effectively restore degraded terrestrial, freshwater and marine ecosystems across the globe".
This one in Twickenham will be the sixth of the series - after Brussels, Houston, New York, Detroit and Seattle.
See the full application here.